首款微型荧光显微镜，镜随借助这一设备，而现在有一种新型显微镜，不止如此，但是其中的材料可以使用更加廉价的零件来代替，随时看清大脑

科学家经常用小鼠进行各种各样的研究，而传统的显微镜不仅观测的数量少，

目前首款微型显微镜的价格大概在5万美元，此外它还能应用到除了小鼠之外的其他动物身上。重量不到2克。

科学家经常用小鼠进行各种各样的研究，

Miniaturized integration of a fluorescence microscope

 Kunal K Ghosh, Laurie D Burns, Eric D Cocker, Axel Nimmerjahn, Yaniv Ziv, Abbas El Gamal & Mark J Schnitzer

The light microscope is traditionally an instrument of substantial size and expense. Its miniaturized integration would enable many new applications based on mass-producible, tiny microscopes. Key prospective usages include brain imaging in behaving animals for relating cellular dynamics to animal behavior. Here we introduce a miniature (1.9 g) integrated fluorescence microscope made from mass-producible parts, including a semiconductor light source and sensor. This device enables high-speed cellular imaging across ~0.5 mm2 areas in active mice. This capability allowed concurrent tracking of Ca2+ spiking in >200 Purkinje neurons across nine cerebellar microzones. During mouse locomotion, individual microzones exhibited large-scale, synchronized Ca2+ spiking. This is a mesoscopic neural dynamic missed by prior techniques for studying the brain at other length scales. Overall, the integrated microscope is a potentially transformative technology that permits distribution to many animals and enables diverse usages, such as portable diagnostics or microscope arrays for large-scale screens.

文献链接：https://www.nature.com/nmeth/journal/v8/n10/full/nmeth.1694.html

这种微型荧光显微镜是由美国斯坦福大学的神经科学家们发明的，研究发布在9月11日的《自然—方法》（Nature Methods）杂志上。它能观测多达200个脑细胞的活动情况，又或是训练它们来嗅探炸弹。它的优势还远不止如此，但在实验中，

最新评论